648 Diclofenac Dithylamine 1.16%w/w, Linseed Oil 3%w/w, Methyl Salicylate 10%w/w and Menthol 5%w/w Spray

648 is a topical spray formulated with Diclofenac Diethylamine 1.16% w/w, Linseed Oil 3% w/w, Methyl Salicylate 10% w/w, and Menthol 5% w/w. Designed to provide fast and effective relief from muscular and joint pain, this spray combines anti-inflammatory and soothing ingredients to help reduce pain, swelling, and stiffness. Its convenient spray format ensures easy application for targeted pain management.

Diclofenac diethylamine + Linseed Oil + Methyl Salicylate + Menthol is a combination of four medicines: Diclofenac diethylamine , Linseed Oil , Methyl Salicylate and Menthol. Diclofenac diethylamine and Menthol are non-steroidal anti-inflammatory drugs (NSAIDs) which work by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Linseed Oil is a plant-based oil which further reduces inflammation and improves blood circulation at the site of application.It also increases the penetration of Diclofenac diethylamine through the skin. Methyl Salicylate produces a cooling effect on the skin.

This topical spray combines anti-inflammatory and analgesic agents to provide fast and effective relief from muscle, joint, and arthritis-related pain and inflammation.

Composition and Mechanism of Action

• Diclofenac Diethylamine (1.16% w/w): A non-steroidal anti-inflammatory drug (NSAID) that works by blocking chemical messengers responsible for pain and inflammation in tissues.

• Linseed Oil (3% w/w): A plant-based oil that reduces inflammation and enhances blood circulation locally, also increasing the penetration of Diclofenac through the skin for better efficacy.

• Methyl Salicylate (10% w/w): Acts as a counter-irritant producing a cooling sensation that soothes the skin and underlying tissues, helping to relieve pain.

• Menthol (5% w/w): Provides a cooling and warming sensation that distracts the nerves from deeper muscle and joint pain and enhances local blood flow.

Uses and Indications

This spray is primarily used for:

• Relief of musculoskeletal pain such as strains, sprains, and muscle soreness

• Management of joint pain from osteoarthritis and rheumatoid arthritis

• Reduction of inflammation, swelling, and stiffness in affected areas

• Alleviating discomfort associated with sports injuries and soft tissue inflammation

Application and Safety

• Apply the spray directly to the affected area and gently massage it into the skin.

• Wash hands thoroughly after applying to avoid contact with eyes or mucous membranes.

• Use as directed by a healthcare provider, usually multiple times daily depending on the severity of symptoms.

• Avoid use on broken or irritated skin, open wounds, or mucous membranes.

• Possible side effects include mild skin irritation, redness, itching, or burning, which usually subside with continued use. Discontinue use and consult a doctor if severe reactions occur.

• It is recommended to complete the entire treatment course to prevent recurrence of pain.

Advantages of Combination Spray

• Multi-action formula targeting pain and inflammation through various pathways for enhanced relief

• Deep skin penetration via linseed oil boosting Diclofenac’s effectiveness

• Cooling sensation from methyl salicylate and menthol provides instant soothing comfort

• Convenient topical application that avoids systemic side effects associated with oral NSAIDs

• Suitable for acute and chronic pain conditions related to joints and muscles